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Clinical Practice Guidelines

  • Oncological emergencies: Hyperleukocytosis
    www.rch.org.au/clinicalguide/guideline_index/Oncological_emergencies__Hyperleukocytosis/
    is important Children with high count leukaemia (hyperleukocytosis) are at risk of death or serious …. Hyperleukocytosis should prompt consideration of possible acute leukaemia. Leukostasis (symptomatic … of complications from hyperleukocytosis depends on the type of leukaemia, some types of acute myeloid leukaemia …
  • Antifungal prophylaxis for children with cancer or undergoing haematopoietic stem cell transplant
    www.rch.org.au/clinicalguide/guideline_index/Antifungal_prophylaxis_for_children_with_cancer_or_undergoing_haematopoietic_stem_cell_transplant/
    High-risk/very-high risk acute lymphoblastic leukaemia (ALL) in intensive treatment phases Acute myeloid … leukaemia (AML) Relapsed acute leukaemia (ALL and AML) Allogeneic HSCT with acute Grade II-IV GvHD … on Infections in Leukaemia. J Antimicrob Chemother. 2018 Tragiannidis A et al. Plasma explosure following …
  • Petechiae and purpura
    www.rch.org.au/clinicalguide/guideline_index/Fever_and_Petechiae_Purpura/
    or accidental injury Haematological Immune thrombocytopenia (ITP)   Malignancy including acute leukaemia …
  • Fever and suspected or confirmed neutropenia
    www.rch.org.au/clinicalguide/guideline_index/Fever_and_suspected_or_confirmed_neutropenia/
    with recurrent neutropenia. High risk cancer treatment protocols Acute myeloid leukaemia (AML) treatment; Acute … lymphoblastic leukaemia (ALL) induction, ALL delayed intensification, infant ALL; lymphoma induction; allogeneic …
  • Cervical lymphadenopathy
    www.rch.org.au/clinicalguide/guideline_index/Cervical_lymphadenopathy/
    lymphadenopathy. Systemic features of fatigue or myalgia Malignancy (lymphoma, leukaemia) Consider if prolonged …
  • The acutely swollen joint
    www.rch.org.au/clinicalguide/guideline_index/The_acutely_swollen_joint/
    present with papular or purpuric rash Polyarthritis Malignancy Leukaemia Bone/soft tissue malignancy …
  • Anaemia
    www.rch.org.au/clinicalguide/guideline_index/Anaemia/
    /aplastic anaemia Causes Acute leukaemia, aplastic anaemia, infiltrative disorders Drugs (eg cytotoxics …
  • Acute scrotal pain or swelling
    www.rch.org.au/clinicalguide/guideline_index/Acute_scrotal_pain_or_swelling/
    /leukaemia Typical age group Infants Peri-pubertal 3-7 years 1-8 years Fever Unusual Unusual Unusual Possible …
  • Immune thrombocytopenic purpura
    www.rch.org.au/clinicalguide/guideline_index/Immune_thrombocytopenic_purpura/
    , anticoagulants or other anti-platelet medications) Differential diagnoses Leukaemia Bacterial or viral infection …
  • The penis and foreskin
    www.rch.org.au/clinicalguide/guideline_index/The_penis_and_foreskin/
    in childhood The commonest causes in children are sickle cell disease (65%), leukaemia (10%) and trauma (10 …