In this section
Long-term outcomes of children born with
colorectal conditions – this project aims to understand the well-being of
children who have undergone surgical repair for an anorectal malformation or
Hirschsprung disease at The Royal Children’s Hospital. It began in 2015 and
follows children with surveys administered cross-sectionally and longitudinally.
Long-term outcomes of parents of children
born with colorectal conditions – this project aims to understand the
well-being of families caring for children with anorectal malformation or
Hirschsprung disease at The Royal Children’s Hospital. It began in 2018 and
follows families with surveys administered cross-sectionally and
Adolescent transition of care – this
project utilises a qualitative approach to understanding the experience of
adolescents transitioning from the paediatric healthcare setting to adult
Parental experience of anal dilatation and
clinician education – this project explores the experiences of parents who
have needed to perform anal dilatation as part of their child’s care after
surgery for an anorectal malformation. It is seeking to understand the factors
affecting parental experiences of this therapeutic procedure, and how access to
specialist services, such as those provided by the CPRS, may be beneficial.
Colonic and anorectal motility patterns in
children – this project aims to characterise the colonic and anorectal
motility patterns in children with an anorectal malformation or Hirschsprung
disease. Commenced in 2020, this project uses the novel technique of
high-resolution manometry to identify motility patterns and their relationship
to symptoms of bowel dysfunction.
Defining the functional pathology of
Hirschsprung disease – this
project aims to investigate the different cell types within the large bowel in
children with Hirschsprung disease. Using novel cell-imaging techniques, we
compare bowel tissue from children with Hirschsprung disease with bowel tissue
obtained from children undergoing other types of surgery.
Determining the role for stem cell therapies
in Hirschsprung disease – this
project aims to take a systematic approach to developing stem cell therapies
for children affected by Hirschsprung disease. Using an existing animal model,
we are investigating the key steps requiring to advance cell therapies that
will be appropriate and safe for human use.
Informing the psychological care of children
and their families – this project aims to inform
models of care to provide specialised psychological support for families of
children with colorectal conditions. The knowledge of what families need from
psychological support within the CPRS will inform current care and promote
better psychological outcomes in these children and families.
life outcomes for children with anorectal malformations – this project, in
collaboration with Nationwide Children’s Hospital (Columbus, Ohio, USA), aims
to identify the factors that impact upon the long-term quality of life outcomes
for children born with an anorectal malformation.
COVID Resilience – this project aims to understand
how local restrictions to manage the COVID-19 pandemic have affected the
wellbeing of children with a variety of chronic health conditions, and how this
changes over time. The project is led by researchers from the Clinical Sciences
Theme at the Murdoch Children’s Research Institute, in collaboration with a
number of services and departments at The Royal Children’s Hospital. The CPRS
will is inviting families of children with chronic constipation to take part.
Your child has an ARM, HD or chronic
Your participation will help us improve our
delivery of care and patient outcomes
The project may not benefit your child directly,
but will help other patients and families in the future
You will have the opportunity to contribute to
the research evidence
Whether you choose to take part in a research
study or decide not to, your choice will not impact the care your child
receives at the RCH or the CPRS
If you do agree to take part in a research
project, you can also choose to stop taking part (withdraw) from the project at
All projects have been approved by the Human
Research Ethic Committee at The Royal Children’s Hospital
MCRI research profiles
RCH Research and Governance Office
Please contact the research team or a member of the CPRS if
you are interested in hearing more about our projects or being involved.