| Analgesic
 | Route | Dose | Maximum daily dosing | Notes/onset of   action | 
        
            | Sucrose (any concentration eg 24%, 33%)
 | PO | Preterm (corrected age 32-40/40 weeks): 0.2-0.5 mL per procedure 
                    <1 month: 0.5-1 mL per procedure 1-18 months: 1-2 mL per procedure | Preterm: max 2.5 mL/day
 <3 months: max 5 mL/day
 ≥3 months: max 10 mL/day | Children 0-18 months (most effective in children
                    <6 months)  Provide one-quarter of dose to anterior tongue 2 minutes prior to painful procedure, with dummy if available. Continue in small increments as required Analgesic effect may last 5-8 minutes from administration | 
        
            | Paracetamol | PO | 15 mg/kg (max 1 g)4-6 hourly
 | Birth-1 month:60 mg/kg/day
 >1 month: 90 mg/kg/day (max 4 g) for severe pain for max 48 hours, then 60 mg/kg/day subsequently
 | Onset of action 30 minutes Oral route is preferred Dose on ideal body weight Administer commercial syrup carefully as available in several concentrations | 
        
            | PR | 15-20 mg/kg (max 1 g)6 hourly
 | 
                    <1 month: 60 mg/kg/day >1 month: 90 mg/kg/day (max 4 g) for max 48 hours, then 60 mg/kg/day subsequently
 | If not tolerated orally  Rectal absorption can be delayed and erratic Dose on ideal body weight125 mg, 250 mg, 500 mg suppositories available
 PR medication should be avoided in immunocompromised children | 
        
            | IV | 
                    <1 month: 10 mg/kg 6 hourly
 
 >1 month:
 15 mg/kg (max 1 g) 6 hourly
 | 
                    <1 month: 40 mg/kg/day    >1 month: 60 mg/kg/day (max 4 g) | Onset of action 5-10 minutes If PO/PR not tolerated More expensive Dose on ideal body weight Dose (mg) and volume (mL) errors have caused significant overdoses in young children  | 
        
            | Ibuprofen | PO | >3 months: 10 mg/kg
 (max 400 mg)
 6-8 hourly with food
 | 30 mg/kg/day (max 2.4 g) | Onset of action 30 minutes Precautions include renal impairment, dehydration, bleeding, anticoagulant use Asthma is not a contraindication Administer commercial syrup carefully as available in several concentrations | 
        
            | Oxycodone   | PO | 1–12 months: 0.05-0.1 mg/kg 4 hourly
 >12 months:
 0.1-0.2 mg/kg (adult dose 5-10 mg) 4 hourly
 | 1-12 months: max 0.6 mg/kg/day     >12 months:max 1.2 mg/kg/day
 | Onset of action 10-30 minutes Higher/more frequent dosing can be used in hospital settings For short term use Do not prescribe for outpatient use if no clear diagnosis  | 
        
            | Morphine | IV/subcut | 
                    <1 month: 0.025 mg/kg, repeat as needed
 1-12 months: 0.05 mg/kg
 >12 months: up to 0.2 mg/kg (max 5-10 mg) | Cumulative maximum: 
                    <1 month:  0.1 mg/kg 4-6 hourly (max 0.6 mg/kg/day) 1-12 months: 0.1 mg/kg 2-4 hourly (max 1.2 mg/kg/day) >12 months: 0.2 mg/kg 2-4 hourly (max 2.4 mg/kg/day) | Rapid onset, peak effect 5-10 minutes Higher/more frequent dosing can be used in hospital settings | 
        
            | Fentanyl  | Intra-nasal | >12 months:1.5 microg/kg
 (max 100 microg) for first dose
 0.75 microg/kg for subsequent doses after10 minutes
 | Total dose of 3 microg/kg/day | Rapid onset (5 minutes) Divide dose between nostrils using atomiser Consider alternative ongoing analgesics after second dose Not recommended
                    <12 months of age | 
        
            | Tramadol | PO/IV | >12 years 0.5-1 mg/kg (max 100 mg) 6 hourly
 | 4 mg/kg/day (max 400 mg) | Onset of action 30-60 minutes Can give up to 2 mg/kg if no risk of sleep apnoea/risk factors for respiratory depression  Avoid in epilepsy (lowers seizure threshold) Avoid in young people on SSRIs (risk of serotonin syndrome)  |