Assoc Prof Richard Leventer

  • Neurology - Richard Leventer

    Consultant Neurologist
    Neuroscience group leader, Murdoch Children's Research Institute and Senior Lecturer, University of Melbourne Department of Paediatrics.

    Biographical Sketch

    A/Prof. Leventer is a paediatric neurologist and a researcher in the neurosciences group of the MCRI. He received his medical training at Monash University (including a BMedSci in biological psychiatry) and trained in general paediatrics and paediatric neurology at the Royal Children's Hospital. He then completed a two-year fellowship in clinical paediatric neurology at Washington University School of Medicine in St. Louis followed by two years as Research Associate in the Department of Human Genetics at the University of Chicago, working in the laboratory of Professors David Ledbetter and William Dobyns as a research associate on the Brain Malformation Research Project. He returned to the RCH as a Consultant Neurologist in July 2001. In October 2007 he received his PhD on the topic of human cortical malformations focussing on polymicrogyria. A/Prof Leventer is the immediate past president of the Australia and New Zealand Child Neurology Society.

    Clinical Interests

    A/Prof Leventer sees patients with all types of neurological disorders. He has particular interests in genetic diseases of the central nervous system and brain malformations. A/Prof Leventer is neurologist to the General Neurogenetics and Genetics of Brain Development Clinics in conjunction with Victorian Clinical Genetics Services. He sees patients in Neurology Outreach Clinics in Traralgon and Warragul.

    Research Interests

    A/Prof Leventer's main research interests are genetic disorders of the central nervous system and magnetic resonance imaging. He is Director of the RCH Brain Malformation Research Program and is a Chief Investigator on the RCH / MCRI Accelerated Gene Identification Project. For more information see:  A/Prof Leventer is involved in collaborative research with the neuropsychology department to better understand how the timing and nature of brain injury influence developmental outcome. He is a member of the Global Leukodystrophy IniAtive (GLIA) and is on the scientific advisory board of Orphanet Australia.

    Selected publications

    Leventer RJ, Jansen FE, Mandelstam SA, Ho A, Mohamed I, Sarnat HB, Kato M, Fukasawa T, Saitsu H, Matsumoto N, Itoh M, Kalnins RM, Chow CW, Harvey AS, Jackson GD, Crino PB, Berkovic SF, Scheffer IE. Is Focal Cortical Dysplasia sporadic? Family evidence for genetic susceptibility. Epilepsia (In Press)

    Howell KB, Kornberg AJ, Harvey AS, Ryan MM, Mackay MT, Freeman JL, Rodriguez Casero MV, Collins KJ, Hayman M, Mohamed A, Ware TL, Clark D, Bruno DL, Burgess T, Slater H, McGillivray G, Leventer RJ. High resolution chromosomal microarray in children with undiagnosed neurological disorders. JPCH, 2013;49:716-24.

    Taft RJ, Vanderver A, Leventer RJ, Damiani SA, Simons C, Grimmond SM, Miller D5, Schmidt J, Lockhart PJ, Pope K, Ru K, Crawford J, de Coo IMF, Juneja M, Verma IC, Prabhakar P, Blaser S, Raiman J, Pouwels PWJ, Bevova M, Abbink TEM, van der Knaap MS, Wolf NI. Rare damaging DARS variants cause Hypomyelination with Brain stem and Spinal cord involvement and Leg spasticity (HBSL), a novel disorder with striking resemblance to the DARS2-associated disease LBSL. AJHG, 2013;92,:774–780

    Leventer RJ, Jansen A, Pilz DT, Stoodley N, Marini C, Dubeau F, Malone J, Mitchell LA, Mandelstam, S, Scheffer IE, Berkovic SF, Andermann E, Andermann F, Guerrini R, Dobyns WB. Clinical and imaging heterogeneity of polymicrogyria: a study of 328 patients. Brain 2010; 133:1415-27.

    Anderson V, Spencer-Smith M, Leventer R, Coleman L, Anderson P, Williams J, Greenham M, Jacobs R. Childhood brain insult: can age at insult help us predict outcome? Brain. 2009;132:45-56.

    Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003 34:274-85.

    Leventer RJ, Cardoso C, Ledbetter DH and Dobyns WB. LIS1: from cortical malformation to essential protein of cellular dynamics. Trends Neurosci. 2001; 24:489-92

    Leventer RJ, Phelan EM, Coleman LT, Kean MJ, Jackson GD, and Harvey AS. Clinical and imaging features of cortical malformations in childhood. Neurology 1999;53:715-722


    Link to all publications:


     Contact information

    Mailing address: Department of Neurology
    Royal Children's Hospital
    Flemington Road
    Parkville, Victoria 3052,
     Phone: +613-9345 5661 
     Fax: +613-9345 5977