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Despite its many challenges, oncofertility continues to rapidly advance. In 2012 in response to calls from cancer survivors and their families, a multidisciplinary taskforce involving major Victorian Comprehensive Cancer Centre (VCCC) partners was established across the paediatric and adult sectors to address the unmet needs around fertility. Respectful exchange has enabled the introduction of new ethical and integrated models of care. It is in this spirit that we welcome families, clinicians, scientists and policymakers to the second National Oncofertility Summit at The Royal Children’s Hospital (RCH). We hope to explore potential solutions for the most challenging issues in oncofertility care and survivorship. We thank our partners for contributing to the success of this event: The University of Melbourne, The Royal Women’s Hospital, The Youth Cancer Action Board Peter MacCallum Cancer Centre and Fertility Preservation Taskforce Consumer Advisory group.