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CI Esterase deficiency
True Serum Sickness is a delayed hypersensitivity reaction, triggered by:
Serum Sickness-Like Reaction (SSLRs), which are more common in children, can cause a similar but less severe clinical picture, without measurable immune-complex formation. They are triggered by a variety of drugs, most commonly cefaclor and amoxicillin. Illnesses,
immunisations and occasionally chemicals can also trigger SSLRs.
Explore events in the two - weeks before onset of symptoms:
Explore each symptom in detail:
Differential diagnosis of serum sickness and SSLRs
* Typically show involvement of mucous membranes
Papular, pruritic patches (hives), or morbilliform rash.
Migrate more slowly than true urticaria.
Serum sickness – nearly always >38.5
SSLR – low-grade fever common
Up to 2/3
Knees, wrists, ankles, shoulders, MCP joints
Papular, pruritic patches (hives)
Symmetric, involving palms, soles, face, oral mucosa.
Typical target lesions.
Cough, respiratory symptoms
Unwell. Malaise, myalgia, sore throat, photophobia / conjunctivitis
Child requires care beyond the comfort of the local healthcare facility
For emergency advice and paediatric or neonatal ICU transfers, call
the Paediatric Infant Perinatal Emergency Retrieval (PIPER) Service: 1300 137