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National Haemophilia Guidelines
Haemophilia Foundation Australia
Von Willebrand disease
Clotting Factor (%)
Typical Bleeding Picture
Frequent bleed episodes are common; predominantly into joints & muscles. Bleeding can occur spontaneously or after a minor injury
Can bleed after a minor injury. May have bleeding into joints. Severe bleeds occur with moderate trauma, surgery & invasive procedures
Bleeding occurs with major traumas such as surgery & invasive procedures
Do not delay clotting factor replacement in severe or life-threatening bleeding.
Recombinant clotting factor concentrates are the product of choice. Occasionally children will be treated with plasma-derived concentrates for management of factor VIII/IX inhibitors.
Note that there are two recombinant Factor VIII (FVIII) products available. Whilst it is recommended that children maintain treatment with their established brand of FVIII product, in an emergency situation administration of any brand of recombinant FVIII is acceptable.
See Haemophilia treatments for more information, including the dosing and administration of factor products.
Please note that clotting factor concentrates are not routinely available in all hospitals.
For muscle and joint bleeds P.R.I.C.E will limit bleeding and reduce pain. Initiate on arrival
Assessing any child with haemophilia with bleeding episodes.
Note: consult with the haemophilia treatment centre
For emergency advice and paediatric or neonatal ICU transfers, see Retrieval Services
Last updated October 2019