The Royal Children's Hospital (RCH) Children's Cancer Centre (CCC) is the largest partner in the Victorian Paediatric Integrated Cancer Services (PICS) and is a member of the Victorian Comprehensive Cancer Care program. The CCC is the only provider of complex children's cancer care and stem cell transplantation in the state of Victoria. The CCC is recognised as an international leader in the research and treatment of childhood cancer, each year treating around 300 newly diagnosed cancer patients under the age of 18 and many children receive ongoing treatment and/or active patient follow up.

The CCC aims for the highest standards in diagnosis, research, treatment, and support. The CCC comprises: an inpatient ward with designated bone marrow transplant beds, a day oncology unit, outpatient clinic area including allied health facilities, a dedicated oncology pharmacy, a research program with state-of-the-art laboratory facilities, a clinical trials office and an administrative centre.

As part of the Melbourne Children's the CCC has strong links and affiliations with the University of Melbourne, the Murdoch Children's Research Institute and The Royal Children's Hospital Foundation; as well as the wider community. 

The CCC actively participates in cancer clinical trials and is a full member of the Children's Oncology Group (COG).