Paediatric Intensive Care Unit (PICU)

Research

  • Paediatric intensive care research is an exciting field, which addresses a spectrum of diseases and conditions which continue to challenge our critically ill children. The Royal Children's Hospital intensive care research team are delighted to be part of a number of national and international collaborative studies, as well as undertaking local projects. Our areas of particular interest include cardiac disease, acquired brain injury, lung injury and renal replacement therapy.

    All intensive care staff are encouraged to undertake research, and in addition we have a dedicated group of nurses who together co-ordinate our research projects. This enables us to efficiently screen all children admitted to the unit, each day, for their suitability for inclusion in our projects.

    Data & Research Staff

    All staff from medical, nursing and technology departments within the intensive care unit are encouraged to undertake research. The skills and experience of the intensive care consultant group have provided a strong foundation for the continued growth of research within the unit.

    Staff involved in research are assisted by:

    Data, Quality & Audit Team Leader

    Carmel Delzoppo

    Manager of the Intensive Care Database and responsible for the development, implementation and maintenance of the clinical database in intensive care, and for producing reports and statistics for use in research within the hospital and externally, with particular reference to the collaborative effort with Australian and New Zealand Paediatric Intensive Care Registry. Team leader of the collaborative data and research team.            

    Intensive Care Research Co-ordinator, responsible for monitoring and co-ordinating research projects in the intensive care unit and liasing with staff interested in performing research. Carmel also assists with data collection for the intensive care database and for the organ donor database sponsored by the Red Cross.  Steering Committee member for the Paediatric Study Group in the Clinical trials Group for Australian and New Zealand Intensive Care Society.                                                                          

    Telephone: 61 3 9345 4766  
    e-mail:  carmel.delzoppo@rch.org.au

    Database & Research Assistants

    Claire Daffey, Liz Fletcher, Linda Darragh

    Database & Research Assistants contribute to data collection, maintenance of the intensive care database, audits and clinical research projects. The team also perform PICU patient outcome calls.

    Telephone: 61 3 9345 4766, or ICU data room: 4483 
    e-mail: claire.daffey@rch.org.au, liz.fletcher@rch.org.au, linda.darragh@rch.org.au

    Murdoch Affiliated Research Coordinators

    Carmel Delzoppo

    email: carmel.delzoppo@rch.org.au

    Telephone: 61 3 9345 4766

     

    Research currently running in PICU

     Project Principal Investigator HREC    Contact
     ANZICS Point prevalence project Carmel Delzoppo  33230

    carmel.delzoppo@rch.org.au

    Randomised controlled trial of a combination of Dexamethasone and Adrenaline for Bronchiolitis  Dr Ben Gelbart  

    32119 

     ben.gelbart@rch.org.au

     

    Extracorporeal Life Support (ECLS) in Paediatric Malignancy: Complications and Outcomes:  Dr Graeme MacLaren  

     Graeme.maclaren@rch.org.au

     

    Associations between dysglycemia and outcomes in paediatric extracorporeal membrane oxygenation  Dr Graeme MacLaren 33013 Graeme.maclaren@rch.org.au
    The application of hemofiltration in children receiving Extra-corporeal membrane oxygenation and its impact on clinical outcomes Dr Graeme MacLaren 33012 Graeme.maclaren@rch.org.au
    Safety of therapeutic hypothermia in children receiving veno-arterial extracorporeal membrane oxygenation after cardiac surgery Associate Professor Warwick Butt 33014 warwick.butt@rch.org.au
    Does hyperoxia and hypocapnia affect the outcomes of children receiving extracorporeal membrane oxygenation Dr Johnny Millar 33011 johnny.millar@rch.org.au
    An international point prevalence study of fluid resuscitation practice in paediatric patients in ICU Carmel Delzoppo  32246  carmel.delzoppo@rch.org.au
    An international point prevalence study of infants and children treated for severe sepsis and septic shock in an ICU Dr Johnny Millar

     33043

     Johnny.millar@rch.org.au

    Invasive Group A Streptococcal Infection in PICU Audit protocol Dr Anna Lithgow  

     anna.lithgow@rch.org.au

    Airway management of croup Dr Ben Gelbart  

     ben.gelbart@rch.org.au

    A prospective audit of procalcitonin in a paediatric general and cardiac intensive care unit Dr Ben Gelbart  

     ben.gelbart@rch.org.au

    Characterization of Gene-Environment Interactions Affecting Congenital Heart Disease Outcomes: The GECHO Trial Dr Mike Clifford  

     Michael.clifford@rch.org.au

    Antibiotic point prevalence study in PICU Professor Trevor Duke  

     trevor.duke@rch.org.au

    The first three minutes: development of a teaching package to prepare teams for effective Paediatric Basic Life Support Jo McKittrick   jo.mckittrick@rch.org.au
    Single centre experience with haemofiltration and plasmafiltration in children Associate Professor Warwick Butt  

     warwick.butt@rch.org.au

    The use of Extracorporeal life support following cardiac surgery in children Associate Professor Warwick Butt   warwick.butt@rch.org.au
    The use of TEG in children in ICU Associate Professor Warwick Butt   warwick.butt@rch.org.au
    Use of Brain Nature tic Peptide and tissue Doppler in assessing cardiac performance during weaning from mechanical support Associate Professor Warwick Butt   warwick.butt@rch.org.au
    Demographics of children with pneumonia admitted to Intensive Care and the effectiveness of mechanical ventilation, oscillation and ECMO in children with pneumonia Associate Professor Warwick Butt   warwick.butt@rch.org.au
    Epidemiology of Paediatric Chronic Critical Care Illness in Australia and New Zealand: Population based study looking at trends and long term-survival outcomes of children with Chronic Critical Illness in Australia and New Zealand Dr Siva Namachivayam   siva.namachivayam@rch.org.au
    Impact of High-Frequency Oscillatory ventilation on Outcomes in Paediatric Intensive Care Dr Siva Namachivayam   siva.namachivayam@rch.org.au
    Effect of Fluid balance on Survival Outcomes in Children with varying lengths of stay post cardiac surgery Dr Siva Namachivayam   siva.namachivayam@rch.org.au
    Effect of having a paralysed diaphragm on ICU course and long-term outcome in infants with Single-Ventricle Circulation Dr Siva Namachivayam   siva.namachivayam@rch.org.au
    Evaluation of an ECLS nurse-led anticoagulation protocol: a before & after study Amy Johansen   amy.johansen@rch.org.au
    Assessing the impact of a pain and sedation algorithm in the paediatric intensive care environment Grace Larson   grace.larson@rch.org.au
    Rhabdomyolysis in Children in a Paediatric intensive Care Unit Ben Gelbart   ben.gelbart@rch.org.au
    Application of Therapeutic Hypothermia in the Paediatric Intensive Care Unit (PICU) Associate Professor Warwick Butt   warwick.butt@rch.org.au
    Extubation in PICU: an institutional study of outcomes, prediction and prevention of failure Jessica Elliot   Jessica.elliott2@rch.org.au
    Neurological Multimodality Monitoring Associate Professor Warwick Butt   warwick.butt@rch.org.au
    Bacteraemia and pneumonia in a tertiary paediatric intensive care unit: an 11 year study. Professor Trevor Duke   trevor.duke@rch.org.au
    Brain injury in paediatric patients receiving VA-ECMO or cVAD for cardiac support Dr Johnny Millar   johnny.millar@rch.org.au
    Transport time and outcome in childhood trauma Dr Rob Henning   Robert.henning@rch.org.au
    Ethical basis of allocation of health care resources to rural children Dr Rob Henning   Robert.henning@rch.org.au
    Outcome of MET Royal Children’s Hospital 2002 onwards Associate Professor James Tibballs   james.tibballs@rch.org.au

     

    Goto Top

    Published Work 2013

    MacLaren G, Brain MJ, Butt WW , Song L, Best D, Delzoppo C, entitled "Hemolysis in pediatric patients receiving centrifugal-pump extracorporeal membrane oxygenation: Incidence, risk factors and outcomes” , CCMED-D-12-02085R3 . Pediatr Crit Care Med 2013( In press)

    MacLaren G, Brain MJ, Butt WW. ECMO in acute and chronic adult respiratory failure: recent trends and future directions. Minerva Anestesiol [in press]

    MacLaren G, Butt W, Peek G, Lynch W, Bartlett RH. Mistaking complications of critical illness for those of critical care. Crit Care Med [in press]

    Brain MJ, Butt W, MacLaren G. Physiology of ECLS. In: Extracorporeal Life Support for Patients with ARDS. Schmidt GA (Ed). 1st Edition. Springer [in press]

    Butt W.  Quality of Care Leads to Quality of Life after Trauma in Children. Pediatric Critical Care Medicine (in press 2013)

    Maclaren G, Brain M, Butt W. ECMO in acute and chronic adult respiratory failure: recent trends and future directions. Minerva Anestesiol.  (in press 2013)

    W Butt. Minimise stress and maximise clinical outcome. Pediatric Critical Care Medicine. 2013 

    J Varley, D Pilcher, W Butt, P Cameron. A retrospective study into the outcomes of self-injured patients requiring ICU management.. (submitted)

    Horan M, Butt W, and Monagle P. The Thromboelastogram: Normal values in critically ill children, (in press, Thrombosis)

    Horan M, Butt W, and Monagle P. Does Hypothermia effect accurate measurement of Blood Clotting (in press, Thrombosis)

    Casswell G, Pilcher D, Martin R, Pelligrino V, Marasco S, Robertson C, Butt W, Snell G, Westall G. Buying Time: The Use of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation in Pediatric Patients. The Journal of Heart and Lung Transplantation. Vol 32, Issue 4 Supplement. April 2013

    Yoong, MS, D’Udekem, Y, Roberston CF, Brizard CP, Butt WW, Konstantinov IE. Tracheal Repair in Children: Reducation of Mortality with Advent of Slide Tracheoplasty. ANZ Journal of Surgery. 2013

    MacLaren, G, Butt W, Shekerdemian L. PCICS/ELSO Joint Statement on Pediatric Mechanical Circulatory Support in Children: A Consensus Review.. Pediatr Crit Care Med, June 2013

    Long EJ. Shann F. Pearson G. Buckley D. Butt W. A randomised controlled trial of plasma filtration in severe paediatric sepsis.  Critical Care & Resuscitation. 15(3):198-204, 2013 Sep

    Downie L. Armiento R. Subhi R. Kelly J. Clifford V. Duke T. “Community-acquired neonatal and infant sepsis in developing countries: efficacy of WHO's currently recommended antibiotics--systematic review and meta-analysis. [Review]” Archives of Disease in Childhood. 98(2):146-54, 2013 Feb

    Brink, F., Duke, T.; Evans, J.High-Flow Nasal Prong Oxygen Therapy or Nasopharyngeal Continuous Positive Airway Pressure for Children With Moderate-to-Severe Respiratory Distress?. PCCM  Sep 13 Vol 7 pg  

     Chong A, MacLaren G, Chen R, Connelly KA. Perioperative applications of deformation (myocardial strain) imaging with speckle-tracking echocardiography. J Cardiothorac Vasc Anesth [in press] 

    MacLaren G. A fresh perfection. Intensive Care Med 2013; 39(8):1475-1476

    MacLaren G, Dodge-Khatami A, Dalton H. Joint statement on mechanical circulatory support in children: a consensus review from the Pediatric Cardiac Intensive Care Society and Extracorporeal Life Support Organization. Pediatr Crit Care Med 2013; 14(5 Suppl): S1-2

    D’Udekem Y, Shime N, Lou S, MacLaren G. Recurrent or prolonged mechanical circulatory support: bridge to recovery or road to nowhere?  Pediatr Crit Care Med 2013; 14(5 Suppl): S69-72 

     Dalton H, Dodge-Khatami A, MacLaren G. Pediatric mechanical circulatory support: future directions. Pediatr Crit Care Med 2013; 14(5 Suppl):S94-95 

    Brown KL, MacLaren G, Marino BS. Looking beyond survival rates: neurological outcomes after extracorporeal life support. Intensive Care Med [in press] 

    MacLaren G. Optimizing fluid management in children on extracorporeal life support. Pediatr Crit Care Med [in press]

     MacLaren G. Long-term outcomes after extracorporeal life support: what happens to the survivors? Pediatr Crit Care Med 2013; 14(6):646-647 

     MacLaren G. Endovascular therapy in extracorporeal membrane oxygenation survivors: sailing out into open water. Pediatr Crit Care Med 2013; 14(1):103-104

    MacLaren G, Dodge-Khatami A, Dalton HJ, Adachi I, Almodovar M, Annich GM, Bartlett RH, Bronicki R, Brown K, Butt W, Cooper D, Demuth M, D’Udekem Y, Fraser C, Guerguerian AM, Heard M, Horton S, Ichord R, Jaquiss R, Laussen P, Lequier L, Lou S, Marino B, McMullan M, Ogino M, Peek G, Pretre R, Rodefeld M, Schmidt A, Schwartz S, Shekerdemian L, Shime N, Sivarajan B, Stiller B, Thiagarajan R. Joint statement on mechanical circulatory support in children: a consensus review from the Pediatric Cardiac Intensive Care Society and Extracorporeal Life Support Organization. Pediatr Crit Care Med 2013; 14(5 Suppl):S1-118 

    Shime N, Hosokawa K, MacLaren G. Does cooling really improve outcomes in patients with septic shock? Am J Respir Crit Care Med 2013; 187(11):1274-1275 

    Shime N, MacLaren G. Supplemental parenteral nutrition in critically ill patients. Lancet 2013; 381(9879):1715-1716

    MacLaren G, Conrad S, Dalton H. Extracorporeal Life Support. In: Rogers’ Textbook of Pediatric Intensive Care. Shaffner H, Nichols D (Eds). Fifth Edition. Lippincott Williams & Wilkins [in press] 

    Larson G., Arnup S., Clifford M., Evans J. How does the introduction of a pain and sedation management guideline in the paediatric intensive care impact on clinical practice? A comparison of audits pre and post guideline introduction. 2013 Australian Critical Care Nursing -202; No. of Pages 6 

    Larson, G., Takacs, L. & McKenzie I. (July, 2013)."Behave yourself" Children and Adults Behaviour During Routine Procedures. Poster presented at the Internation Symposium on Pediatric Pain, Stockholm, Sweden.

    Larson, G. Legrigore, I. & Clifford, M. (July, 2013). The Introduction of a Pain Assessment Tool into the Paediatric Intensive Care Unit. Poster presented at the Internation Symposium on Pediatric Pain, Stockholm, Sweden.

     

     

    Straney, L.; Clements, A.; Parslow, Roger C.; Pearson, G.; Shann, F.; Alexander, J.; Slater, A.; for the ANZICS Paediatric Study Group and the Paediatric Intensive Care Audit Network “ Paediatric Index of Mortality 3: An updated model for predicting mortality in pediatric Intensive care. [Article]” Pediatric Critical Care Medicine. September 2013 Vol 14 Num 7 pg Shann F.  Nonspecific effects of vaccines and the reduction of mortality in children. Clinical Therapeutics. 35(2):109-14, 2013 Feb.

     

    Published Work 2012

     

    d'Udekem Y. Cheung M. Butt W. Shann F. Brizard CP. “Transposition with intact septum diagnosed at nine months: arterial switch?  Asian Cardiovascular & Thoracic Annals. 20(3):333-4, 2012 Jun.

    Namachivayam, P; Taylor, A; Montague, T; Moran, K; Barrie, J; Delzoppo, C; Butt, W. “Long-stay children in intensive care: Long-term functional outcome and quality of life from a 20 yr institutional study.” Pediatric Critical Care Medicine. 13(5):520-528, September 2012.

    Gupta P, McDonald R, Gossett J, Butt W, Shinkawa T, Imamura M, Bhutta A, Prodhan P.  “A Single Center Experience of Extubation Failure in Infants Undergoing the Norwood Operation.” The Annals of Thoracic Surgery. May 2012 

    Rippel C. South M. Butt WW. Shekerdemian LS. Vitamin D status in critically ill children. Intensive Care Medicine. 38(12):2055-62, 2012 Dec. [Journal Article]

    Dalton HJ. Butt WW. Extracorporeal life support: an update of Roger’s textbook of Paediatric Intensive Care. [review]

    MacLaren G, Butt W. Sepsis and ECMO. In: ECMO: Extracorporeal Cardiopulmonary Support in Critical Care. Fourth Edition.

    Smalley N, MacLaren G, Best D, Paul E, Butt W. Outcomes in children with refractory pneumonia supported with extracorporeal membrane oxygenation. Intensive Care Med 2012; 38(6):1001-1007 

    D'Udekem Y. Xu MY. Galati JC. Lu S. Iyengar AJ. Konstantinov IE. Wheaton GR. Ramsay JM. Grigg LE. Millar J. Cheung MM. Brizard CP. “Predictors of survival after single-ventricle palliation: the impact of right ventricular dominance.” Journal of the American College of Cardiology. 59(13):1178-85, 2012 Mar 27.

    Cove ME, Spelman D, MacLaren G. Infectious complications of cardiac surgery: a clinical review. J Cardiothorac Vasc Anesth 2012; 26(6):1094-1100 

    Cove ME, MacLaren G, Federspiel WJ, Kellum JA. Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future. Crit Care 2012; 16(5):232

     MacLaren G. Medicine, art and the death of Franz Liszt. Internal Med J 2012; 42(5):575-577 

    MacLaren G, Combes A, Bartlett RH. Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era. Intensive Care Med 2012; 38(2):210-220  [Article of the Month]

     MacLaren G. Lessons in advanced extracorporeal life support. Crit Care Med 2012; 40(9):2927-2731

     Bartlett RH, MacLaren G, Annich G. The Future of Extracorporeal Life Support. In: ECMO: Extracorporeal Cardiopulmonary Support in Critical Care. Fourth Edition.

    Annich G, Lynch W, MacLaren G, Wilson J, Bartlett RH (Eds). ELSO, Ann Arbor. 2012: 435-438

    Annich G, Lynch W, MacLaren G, Wilson J, Bartlett RH (Eds). ELSO, Ann Arbor. 2012: 397-410

    Annich G, MacLaren G. Preface to Sections II-V. In: ECMO: Extracorporeal Cardiopulmonary Support in Critical Care. Fourth Edition. 

    Annich G, Lynch W, MacLaren G, Wilson J, Bartlett RH (Eds). ELSO, Ann Arbor. 2012: 105-106

    Annich G, MacLaren G. Preface. In: ECMO: Extracorporeal Cardiopulmonary Support in Critical Care. Fourth Edition.

     Annich G, Lynch W, MacLaren G, Wilson J, Bartlett RH (Eds). ELSO, Ann Arbor. 2012: xiii  

    Tibballs, J. Aickin, R. Nuthall, G. Australian and New Zealand Resuscitation Councils. “Basic and advanced paediatric cardiopulmonary resuscitation - guidelines of the Australian and New Zealand Resuscitation Councils 2010.” Journal of Paediatrics & Child Health. 48(7):551-5, 2012 Jul.

    Bhatia, N. Tibballs, J. “Legal clarification of "loss of chance of a better outcome" in Australia.” Comment Medical Journal of Australia. 197(8):446, 2012 Oct 15.

    Tibballs, J. Li, R. Tibballs, H A. Gershwin, L. Winkel, K. D. “Australian carybdeid jellyfish causing "Irukandji syndrome". [Review] Toxicon. 59(6):617-25, 2012 May.

    Bhatia, N. Tibballs, J. “Legal clarification of "loss of chance of a better outcome" in Australia.” Med J Aust. 196(3):167-8, 2012 Feb 20.

    McKeever S. Johnston L. Davidson A. “A review of the utility of EEG depth of anaesthesia monitors in the paediatric intensive care environment. [Review]” Intensive & Critical Care Nursing. 28(5):294-303, 2012 Oct. 

    Kinney S. Lima S. McKeever S. Twomey B. Newall F. “Employing a clinical governance framework to engage nurses in research.” J Nurs Care Qual. 27(3):226-31, 2012 Jul-Sep

    McKeever S. Johnston L. Davidson AJ.” An observational study exploring amplitude-integrated electroencephalogram and spectral edge frequency during paediatric anaesthesia.”    Anaesthesia & Intensive Care. 40(2):275-84, 2012 Mar.

    Chisti MJ. Duke T. Robertson CF. Ahmed T. Faruque AS. Ashraf H. La Vincente S. Bardhan PK. Salam MA. “Clinical predictors and outcome of hypoxaemia among under-five diarrhoeal children with or without pneumonia in an urban hospital, Dhaka, Bangladesh.” Tropical Medicine & International Health. 17(1):106-11, 2012 Jan.

    Ramakrishna B. Graham SM. Phiri A. Mankhambo L. Duke T. “Lactate as a predictor of mortality in Malawian children with WHO-defined pneumonia.” Archives of Disease in Childhood. 97(4):336-42, 2012 Apr.

    Jayawardena N. Subhi R. Duke T. “The Western Pacific Regional Child Survival Strategy: progress and challenges in implementation.” Journal of Paediatrics & Child Health. 48(3):210-9, 2012 Mar.

    Shann F.Australia, immunisation, GAVI, and the non-specific effects of vaccines.  Australian & New Zealand Journal of Public Health. 36(6):569-71, 2012 Dec.

    Yong MS. Shann F. d'Udekem Y. Cheung MH. Weintraub RG. Brizard CP. Konstantinov IE. “Hemodynamic index for risk stratification after neonatal total anomalous pulmonary venous drainage repair.  Annals of Thoracic Surgery. 94(5):1584-7, 2012 Nov

    Shann F.Commentary: BCG vaccination halves neonatal mortality.” Pediatric Infectious Disease Journal. 31(3):308-9, 2012 Mar

    Shann F.The new decade of vaccines.” Lancet. 379(9810):26; author reply 27, 2012 Jan 7. [Comment. Letter]

     

    Published Work 2011

     

    Shekerdemian L, Shann F, Butt W. “Rotating Inotrope Therapy in a Pediatric Population with Decompensated Heart Failure.” Pediatric Critical Care Medicine. Jan 2011 

    Butt WW. Checklists, guidelines, and protocols: a prescription for improved outcomes. Pediatric Critical Care Medicine. 12(3):352-3, 2011 May.  [Comment. Editorial]

     Fitzgerald MC. Chan JY. Ross AW. Liew SM. Butt WW. Baguley D. Salem HH. Russ MK. Deasy C. Martin KE. Mathew JK. Rosenfeld JV.  A synthetic Haemaglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to anaemia following trauma. Medical Journal of Australia. 194(9):471-3, 2011 May 2. [Case Reports. Journal Article]

    MacLaren G, Butt W. Reply to Prodhan and colleagues. Pediatr Crit Care Med 2011; 12(5):606-607 

    MacLaren G, Butt W, Best D, Donath S. Central extracorporeal membrane oxygenation for refractory pediatric septic shock. Pediatr Crit Care Med 2011; 12(2):133-136

    W Butt. “Has extracorporeal membrane oxygenation finally arrived for resuscitation and stabilization for critically ill patients?” Critical Care Medicine 2011 Vol39, No5

    Rudan I. El Arifeen S. Bhutta ZA. Black RE. Brooks A. Chan KY. Chopra M. Duke T. Marsh D. Pio A. Simoes EA. Tamburlini G. Theodoratou E. Weber MW. Whitney CG. Campbell H. Qazi SA. WHO/CHNRI Expert Group on Childhood Pneumonia. “Setting research priorities to reduce global mortality from childhood pneumonia by 2015”. PLoS Medicine / Public Library of Science. 8(9):e1001099, 2011 Sep.

    Catto AG. Zgaga L. Theodoratou E. Huda T. Nair H. El Arifeen S. Rudan I. Duke T. Campbell H. “An evaluation of oxygen systems for treatment of childhood pneumonia. [Review]” BMC Public Health. 11 Suppl 3:S28, 2011.

    Duke T. “Zinc sulphate for treatment and prevention of diarrhoea and other conditions in children in Papua New Guinea.” Papua New Guinea Medical Journal. 54(1-2):17-22, 2011 Mar-Jun.

    Rudan I. El Arifeen S. Bhutta ZA. Black RE. Brooks A. Chan KY. Chopra M. Duke T. Marsh D. Pio A. Simoes EA. Tamburlini G. Theodoratou E. Weber MW. Whitney CG. Campbell H. Qazi SA. WHO/CHNRI Expert Group on Childhood Pneumonia. “Setting research priorities to reduce global mortality from childhood pneumonia by 2015.” PLoS Medicine / Public Library of Science. 8(9):e1001099, 2011 Sep.

    Catto AG. Zgaga L. Theodoratou E. Huda T. Nair H. El Arifeen S. Rudan I. Duke T. Campbell H. “An evaluation of oxygen systems for treatment of childhood pneumonia. [Review]” BMC Public Health. 11 Suppl 3:S28, 2011.

    Duke T. “What the African fluid-bolus trial means.” Lancet. 378(9804):1685-7, 2011 Nov 12.

    Chisti MJ. Duke T. Robertson CF. Ahmed T. Faruque AS. Bardhan PK. La Vincente S. Salam MA. “Co-morbidity: exploring the clinical overlap between pneumonia and diarrhoea in a hospital in Dhaka, Bangladesh.” Annals of Tropical Paediatrics. 31(4):311-9, 2011.

    Duke T. “Randomised trials in child health in developing countries 2011.” Annals of Tropical Paediatrics. 31(4):283-5, 2011.

    Rudan I. El Arifeen S. Bhutta ZA. Black RE. Brooks A. Chan KY. Chopra M. Duke T. Marsh D. Pio A. Simoes EA. Tamburlini G. Theodoratou E. Weber MW. Whitney CG. Campbell H. Qazi SA. WHO/CHNRI Expert Group on Childhood Pneumonia.” Setting research priorities to reduce global mortality from childhood pneumonia by 2015.” PLoS Medicine / Public Library of Science. 8(9):e1001099, 2011 Sep.

    Duke T. “Letter to the editor.” Journal of Paediatrics & Child Health. 47(9):676; discussion 676-7, 2011 Sep. [Comment. Letter]

    La Vincente SF. Peel D. Carai S. Weber MW. Enarson P. Maganga E. Soyolgerel G. Duke T. “The functioning of oxygen concentrators in resource-limited settings: a situation assessment in two countries.” International Journal of Tuberculosis & Lung Disease. 15(5):693-9, 2011 May.”

    Triasih R. Duke T. Robertson CF. “Outcomes following admission to intensive care for asthma.” Archives of Disease in Childhood. 96(8):729-34, 2011 Aug.

    Catto AG. Zgaga L. Theodoratou E. Huda T. Nair H. El Arifeen S. Rudan I. Duke T. Campbell H. “ An evaluation of ozxygen systems for treatment of childhood pneumonia. [Review]” BMC Public Health. 11 Suppl 3:S28, 2011.

    Nunan M. Duke T. “Effectiveness of pharmacy interventions in improving availability of essential medicines at the primary healthcare level. [Review].” Tropical Medicine & International Health. 16(5):647-58, 2011 May.

    Chan J. Nirwati H. Triasih R. Bogdanovic-Sakran N. Soenarto Y. Hakimi M. Duke T. Buttery JP. Bines JE. Bishop RF. Kirkwood CD. Danchin MD. “Maternal antibodies to rotavirus: could they interfere with live rotavirus vaccines in developing countries?”  Vaccine. 29(6):1242-7, 2011 Feb 1.

    MacLaren G, Kluger R, Connelly KA, Royse CF. Comparative feasibility of myocardial velocity and strain measurements using two different methods with transesophageal echocardiography during cardiac surgery. J Cardiothorac Vasc Anesth 2011; 25(2):216-220 

    MacLaren G. Pulmonary complications during cardiac extracorporeal membrane oxygenation: Is bronchoscopy worth the bother? Pediatr Crit Care Med 2011; 12(4):47 -475 

    Spenceley N, MacLaren G, Kissoon N, Macrae DJ. Monitoring in pediatric cardiac critical care: A worldwide perspective. Pediatr Crit Care Med 2011; 12(4):S76-S80

    Checchia PA, Bronicki RA, Allen M, Anas N, Berger JT, Bohn D, Cooper DS, Dalton HJ, Domico M, Finer NN, Gazit AZ, Ghanayem NS, Hazinski MF, Hoffman GM, Kinsella JP, Kissoon N, Klugman D, Laussen P, MacLaren G, Macrae DJ, Perkin DJ, Sivarajan B, Spenceley N, Tucker D, Wernovsky G, Wong H. The Pediatric Cardiac Intensive Care Society Evidence-based Review and Consensus Statement on Monitoring of Hemodynamics and Oxygen Transport Balance. Pediatr Crit Care Med 2011; 12(4):S1-S102 

    Ong J, Ngiam N, Aye W, MacLaren G. Prolonged venovenous extracorporeal membrane oxygenation in a child with leukemia and persistent bacteremia. Pediatr Crit Care Med 2011; 12(6):e395-e397 

    Mansurali N, MacLaren G, Sundar G. Bilateral orbital haematomas in an anticoagulated patient with severe H1N1 influenza. Orbit 2011; 30(2):98-100

     MacLaren G, Combes A, Bartlett RH. Respiratory dialysis is not extracorporeal membrane oxygenation. Crit Care Med 2011; 39(12):2787-2788 

    MacLaren G, Cove M, Kofidis T. Factors associated with the development of acute heart failure in critically ill patients with severe pandemic 2009 influenza (H1N1) infection (reply). Ann Thorac Surg 2011; 91(6):2022

    MacLaren G. Distinction between induction and maintenance dosing in continuous renal replacement therapy. Crit Care 2011; 15(2):419 

    MacLaren G. Evidence and experience with extracorporeal membrane oxygenation. Chest 2011; 139(4):965

    Tibballs J. Yanagihara AA. Turner HC. Winkel K. Immunological and toxinological responses to jellyfish stings. [Review] Inflammation & Allergy Drug Targets. 10(5):438-46, 2011 Oct. 

    Oberender, F., Tibballs, J. “Withdrawal of life-support in paediatric intensive care--a study of time intervals between discussion, decision and death.” BMC Pediatr. 11:39, 2011.

    Tibballs, J. Watson, T. “Symptoms and signs differentiating croup and epiglottitis.” J Paediatr Child Health. 47(3):77-82, 2011 Mar.

    Azzopardi, P., Kinney, S. Moulden, A. Tibballs, J. “Attitudes and barriers to a Medical Emergency Team system at a tertiary paediatric hospital.” Resuscitation. 82(2):167-74, 2011 Feb.

    Tibballs, J., Carter, B. Kiraly, N., Ragg, P., Clifford, M. “External and internal biphasic direct current shock doses for pediatric ventricular fibrillation and pulseless ventricular tachycardia”. PCCM Volume 12(1), January 2011, pp 14-20

    Oberender, F. “Organ donation in Australia.” J Paediatr Child Health. 47(9):637-41, 2011 Sep. 

    Shann F. Chiletti R.Neonatal herpes virus infection: duration of extracorporeal support and the dose of acyclovir.” Pediatric Critical Care Medicine. 12(5):605; author reply 605-6, 2011 Sep. [Comment. Letter]

    Shann F.The nonspecific effects of vaccines and the expanded program on immunization.” Journal of Infectious Diseases. 204(2):182-4, 2011 Jul 15. [Comment. Editorial]

    Al Hanshi S. Shann F.Insulin infused at 0.05 versus 0.1 units/kg/hr in children admitted to intensive care with diabetic ketoacidosis.” Pediatric Critical Care Medicine. 12(2):137-40, 2011 Mar. [Comparative Study. Journal Article]

    Yong MS. d'Udekem Y. Robertson T. Horton S. Dronavalli M. Brizard C. Weintraub R. Shann F. Cheung M. Konstantinov IE. “Outcomes of surgery for simple total anomalous pulmonary venous drainage in neonates.  Annals of Thoracic Surgery. 91(6):1921-7, 2011 Jun

    Shann F.Role of intensive care in countries with a high child mortality rate.” Pediatric Critical Care Medicine. 12(1):114-5, 2011 Jan.

    Shann F. The non-specific effects of vaccines in low income countries.” Archives of Disease in Childhood. 96(1):115, 2011 Jan.

    Shann F.Pneumonia in children in developing countries. [Review] “ Advances in Experimental Medicine & Biology. 697:59-75, 2011 

    Tibballs, J. Yanagihara, A. Turner, H. Winkel, K.” Immunological and toxinological responses to jellyfish stings.” [Review] Inflamm Allergy Drug Targets. 10(5):438-46, 2011 Oct

    Published Work 2010

    Ryerson, L. M., Chiletti, R., Zacharin, M. and Tibballs, J. (2010) 'Two cases of idiopathic infantile arterial calcification', Journal of Paediatrics & Child Health, 46(12), 777-9 

    Silas, R., & Tibballs, J. (2010). Adverse events and comparison of systematic and voluntary reporting from a paediatric intensive care unit. Quality and Safety in Health Care, 19(6), 568-571.

    Clifford, M., & Hunt, R. W. (2010). Neonatal resuscitation. Best Practice & Research Clinical Anaesthesiology, 24(3), 461-474.

    Augustin, S., Horton, A., Butt, W., Bennett, M., & Horton, S. (2010). Centrifugal pump inlet pressure site affects measurement. Perfusion, 25(5), 313.

    Sivarajan, V. B., Best, D., Brizard, C. P., Shekerdemian, L. S., D'Udekem, Y., Horton, S. B., Butt, W. (2010). Improved outcomes of paediatric extracorporeal support associated with technology change. Interact CardioVasc Thorac Surg, 11(4), 400-405.

    Tibballs, J., Carter, B., Kiraly, N. J., Ragg, P., & Clifford, M. (2010). Biphasic DC shock cardioverting doses for paediatric atrial dysrhythmias. Resuscitation, 81(9), 1101-1104.

    Shann, F. (2010). The non-specific effects of vaccines. Archives of Disease in Childhood, 95(9), 662-667.

    Shann, F. M. D. F., Nohynek, H. M. D. P., Scott, J. A. M. F., Hesseling, A. M. D. M., Flanagan, K. L. P. F., & on behalf of the Working Group on The Nonspecific Effects of, V. (2010). Randomized Trials to Study the Nonspecific Effects of Vaccines in Children in Low-Income Countries. [Editorial]: Pediatric Infectious Disease Journal May 2010;29(5):457-461.

    Rutledge, J., Bush, A., Shekerdemian, L., Schulze-Neick, I., Penny, D., Cai, S., Li, J. (2010). Validity of the LaFarge equation for estimation of oxygen consumption in ventilated children with congenital heart disease younger than 3 years--a revisit. American Heart Journal, 160(1), 109-114.

    Shahwan, A., Bailey, C., Shekerdemian, L., & Harvey, A. S. (2010). The prevalence of seizures in comatose children in the pediatric intensive care unit: a prospective video-EEG study. Epilepsia, 51(7), 1198-1204.

    Simpson, C. M., Smolich, J. J., Shekerdemian, L. S., & Penny, D. J. (2010). Urotensin-II contributes to pulmonary vasoconstriction in a perinatal model of persistent pulmonary hypertension of the newborn secondary to meconium aspiration syndrome. Pediatric Research, 67(2), 150-157.

    Shann, F. (2010). Warfare and children. Journal of Paediatrics and Child Health, 46(5), 217-221.

    Shann, F. (2010). Letters to the Editor. Journal of Paediatrics and Child Health, 46(5), 279-280.

    Ben-Meir, M., & Tibballs, J. (2010). Leukocytotic pseudohypoxaemia. Anaesthesia And Intensive Care, 38(3), 566-567.

    Dalton, H. J., & MacLaren, G. (2010). Extracorporeal membrane oxygenation in pandemic flu: insufficient evidence or worth the effort? Critical Care Medicine, 38(6), 1484-1485.

    Fortune, P.-M., & Shann, F. (2010). The motor response to stimulation predicts outcome as well as the full Glasgow Coma Scale in children with severe head injury *. [Article]: Pediatric Critical Care Medicine11(3):339-342.

    Tibballs, J., Carter, B., Kiraly, N., Ragg, P., & Clifford, M. (2010). External and internal biphasic direct current shock doses for pediatric ventricular fibrillation and pulseless ventricular tachycardia. [Article]: Pediatric Critical Care Medicine.

    MacLaren, G., Butt, W., Best, D., & Donath, S. (2010). Central extracorporeal membrane oxygenation for refractory pediatric septic shock. [Article]: Pediatric Critical Care Medicine.

    Namachivayam, P., Shann, F., Shekerdemian, L., Taylor, A., van Sloten, I., Delzoppo, C., Daffey, C., & Butt, W. (2010). Three decades of pediatric intensive care: Who was admitted, what happened in intensive care, and what happened afterward. [Article]: Pediatric Critical Care Medicine.

    Ryerson, L., Alexander, P., Butt, W., Shann, F., Penny, D. J., & Shekerdemian, L. (2010). Rotating inotrope therapy in a pediatric population with decompensated heart failure. [Article]: Pediatric Critical Care Medicine.

    Tibballs, J. (2010). A critique of the apneic oxygenation test for the diagnosis of "brain death". Pediatric Critical Care Medicine: A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies, 11(4), 475-478.

    Shann, F., Nohynek, H., Scott, J. A., Hesseling, A., Flanagan, K., & on behalf of the Working Group on The Nonspecific Effects of, V. (2010). Randomized Trials to Study the Nonspecific Effects of Vaccines in Children in Low-Income Countries. [Editorial]: Pediatric Infectious Disease Journal May 2010;29(5):457-461.

    Tibballs, J., & Weeranatna, C. (2010). The influence of time on the accuracy of healthcare personnel to diagnose paediatric cardiac arrest by pulse palpation. Resuscitation, 81(6), 671-675.

    Alexander, D. C., Butt, W. W., Best, J. D., Donath, S. M., Monagle, P. T., & Shekerdemian, L. S. (2010). Correlation of thromboelastography with standard tests of anticoagulation in paediatric patients receiving extracorporeal life support. Thrombosis Research, 125(5), 387-392.

    Tibballs, J., Henning, R., Robertson, C. F., Massie, J., Hochmann, M., Carter, B.,Bradley, C., .Osborne, A., Stephens, R. A., Scoble, M., Jones, S. E., White, J. and Bryan, D. (2010). A home respiratory support programme for children by parents and layperson carers. Journal of Paediatrics and Child Health, 46(1-2), 57-62.

    Best, D., Butt, W., Membrey, M., Johansen, A., & Horton, S. (2010). Extra corporeal membrane oxygenation in children: "21 today". Australian Critical Care, 23(1), 31-31.

    Snookes, S. H., Gunn, J. K., Eldridge, B. J., Donath, S. M., Hunt, R. W., Galea, M. P., Shekerdemian, L. (2010). A systematic review of motor and cognitive outcomes after early surgery for congenital heart disease. Pediatrics, 125(4), e818-e827.

    Adatia, I., & Shekerdemian, L. (2010). The role of calcium channel blockers, steroids, anticoagulation, antiplatelet drugs, and endothelin receptor antagonists. Pediatric Critical Care Medicine: A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies, 11(2 Suppl), S46-S52.

    Shann, F. (2010). BCG vaccination in developing countries. BMJ, 340(mar15_1), c809.

    Ragg, P. G., & Tibballs, J. (2010). Pressure-created communication between lumens of a multilumen venous catheter. Pediatric Critical Care Medicine: A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies, 11(2), e26-e27.

    Gilmore, H., Millar, K. J., Weintraub, R. G., Hislop, J., Negri, J., Brizard, C. P., d'Udekem, Y. (2010). Australian Experience with VAD as a Bridge to Paediatric Cardiac Transplantation. Heart, Lung and Circulation, 19(1), 26-30.

    Horton, S., d'Udekem, Y., Shann, F., Butt, W., Bennett, M., Best, D., Brizard, C. (2010) Extracorporeal membrane oxygenation via sternotomy for circulatory shock. The Journal of Thoracic and Cardiovascular Surgery, 139(2), e12-e13.

    Simpson, C. M., Smolich, J. J., Shekerdemian, L. S., & Penny, D. J. (2010). Urotensin-II contributes to pulmonary vasoconstriction in a perinatal model of persistent pulmonary hypertension of the newborn secondary to meconium aspiration syndrome. Pediatric Research, 67(2), 150-157.

    Duke, T. (2010). Systemic inflammatory response syndrome and bacteremia in developing countries. Pediatric Critical Care Medicine: A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies, 11(1), 153-154.

    Published Work 2009

    Shann F.Sepsis in babies: should we stimulate the phagocytes?[comment].
    Lancet. 373(9659):188-90, 2009 Jan 17.
     
    Tibballs J. Russell P. Reliability of pulse palpation by healthcare personnel to diagnose paediatric cardiac arrest.Resuscitation. 80(1):61-4, (2009) Jan.

    Butt WW. Outcome assessment--what outcome do we want?. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 10 (1) : 133 - 4; discuss(2009)

    Maclaren G, Butt W. Controversies in paediatric continuous renal replacement therapy. Intensive Care Medicine 35 (4) : 596 - 602(2009)

    Martin J, Shekerdemian LS. The monitoring of venous saturations of oxygen in children with congenitally malformed hearts.. Cardiology in the Young 19 (1) : 34 - 9(2009)

    Newall F, Ignjatovic V, Summerhayes R, Gan A, Butt W, Johnston L, Monagle P. In vivo age dependency of unfractionated heparin in infants and children.. Thrombosis Research 123 (5) : 710 - 4(2009)

    Sivarajan V, Penny DJ, Filan P, Brizard C, Shekerdemian LS. Impact of antenatal diagnosis of hypoplastic left heart syndrome on the clinical presentation and surgical outcomes: The Australian experience.. Journal of Paediatrics and Child Health Epub 2009 : (2009)

    Subhi R. Smith K. Duke T. When should oxygen be given to children at high altitude? A systematic review to define altitude-specific hypoxaemia, Archives of Disease in Childhood. 94(1):6-10, 2009 Jan.

    Published work 2008

    Cantwell-Bartl AM, Tibballs J. "Place, age, and mode of death of infants and children with hypoplastic left heart syndrome: Implications for medical counselling, psychological counselling, and palliative care." J Palliative Care 2008; 24: 76-84.

    Gutierrez J.A., Duke T., Henning R., South M. "Respiratory Failure and Acute Respiratory Distress Syndrome." In Taussig L.M., Landau L.I., etal (eds) Paediatric Respiratory Medicine 2nd Edition Philadelphia: Mosby 2008

    Henning R. Chapter  "Shock and cardiac Disease in Children" Oh TH, ed. Intensive Care Manual. Sydney: Butterworths, 6th ed 2007. (In press.)

    Henning R., "Lung trauma: Near drowning and toxic inhalation." In Taussig L.M., Landau L.I., etal (eds) Paediatric Respiratory Medicine 2nd Edition Philadelphia: Mosby 2008

    Kinney S, Tibballs J, Johnston L, Duke T. "Clinical profile of hospitalized children provided with urgent assistance from a medical emergency team." Pediatrics 2008; 121: e1577-84.

    Linton S., Grant C., Pellegrini J., "Supporting families through discharge from PICU to the ward: The development and evaluation of a discharge information brochure for families." Intensive and Critical Care Nursing, In Press, Corrected Proof, Available online 26 July 2008

    MacLaren G, Kluger R. "The feasibility of myocardial velocity, strain and strain rate measurements during aortic valve replacement surgery." J Cardiothorac Vasc Anesth 2008;22(4):648-649

    MacLaren G, Yeow SF, Spelman D. "Antibiotic prophylaxis in cardiac surgery." Heart 2008;94(5):646

    MacLaren G, Kofidis T, Klima U. "Nonpharmacologic support of the failing right ventricle." Crit Care Med 2008;36(2):662

    Perez A., Butt W., Millar K.J., Best D., Thiruchelvam T., Cochrane AD, Bennett M, Shekerdemian L.S. "Long-distance transport of critically ill children on extracorporeal life support in Australia." Critical Care Resuscitation. 2008 Mar;10(1):34.

    Plunkett A., De Marco P., Vuillermin P., Duke T. "Klebsiella pneumoniae": Archives of Disease in Childhood. Paediatric Intensive Care Unit, Royal Children's Hospital, Melbourne. Department of Haematology, Royal Children's Hospital Melbourne. Child Health Research Unit, Barwon Health.

    Sung V. Massie J. Hochmann MA. Carlin JB. Jamsen K. Robertson CF. "Estimating inspired oxygen concentration delivered by nasal prongs in children with bronchiolitis." [Journal Article. Research Support, Non-U.S. Gov't] Journal of Paediatrics & Child Health. 44(1-2):14-8, 2008 Jan.
     Tibballs J. Paediatric cardiopulmonary resuscitation: recent changes to  guidelines. Journal of Paediatrics and Child Health 2008; 44: 67-9.

    Tibballs J. "Organ donation after cardiac death: legal and ethical justifications for antemortem interventions" (letter). Med J Aust 2008; 188: 186-7.

    Tibballs J, Cantwell-Bartl A. "Outcomes of management decisions by parents for their infants with hypoplastic left heart syndrome born with and without a prenatatal diagnosis." J Paediatr Child Health 2008; 44: 321-4.

    Tibballs J, Thiruchelvam T. "A case of Commotio cordis in a young child caused by a fall." Resuscitation 2008; 77: 139-41.

    Tibballs J. The non-compliance of clinical guidelines for organ donation with Australian statute law.Journal of Law & Medicine. 16(2):335-55, 2008 Oct.

    Tibballs J, van der Jagt E. "Medical emergency and rapid response teams." Pediatr Clin N Am 2008; 55: 989-1010.

    Tibballs J, Russell P. "Reliability of pulse palpation by healthcare personnel to diagnose paediatric cardiac arrest." Resuscitation 2008; 77: Suppl 1; S30.

    Tibballs J, Winkel KD. "Envenomation syndromes". In: Roger's Textbook of Pediatric Intensive Care. 2008. Nichols DG. Ed-in-Chief. Wolters Kluwer/Lippincott, Williams & Wilkins. Philadelphia. pp482-507.

    Previous years published works