Organism

Antibiotic

Those requiring prophylaxis

N. meningitidis

Ciprofloxacin
30 mg/kg (max 125 mg) (<5 years), 250 mg (5-12 years), 500 mg (≥12 years) PO as a single dose

Young children:
Rifampicin 5 mg/kg (<1 month), 10 mg/kg (max 600 mg) (≥1 month) PO bd for 2 days

Pregnancy/contraindication to Rifampicin:
Ceftriaxone 250 mg (≥12 years) 125 mg (<12 years) IM as a single dose or
Ciprofloxacin 30 mg/kg (max 125 mg) (<5 years), 250 mg (5-12 years) 500 mg (≥12 years) PO as a single dose

Index case (if treated only with penicillin) and all intimate household or day care contacts who have been exposed to index case within 10 days of onset.

Any person who gave mouth-to-mouth resuscitation to the index case

HiB

Rifampicin 20 mg/kg (max 600 mg) PO daily for 4 days

Infants <1 month:
Rifampicin 10 mg/kg PO daily for 4 days

Pregnancy/contraindication to Rifampicin:
Ceftriaxone 250 mg IM daily for 2 days

Index case and all household contacts if household includes other children <4 years of age who are not fully immunised.

Index case and all household contacts in households with any infants <12 months of age, regardless of immunisation status.

Index case and all household contacts in households with a child 1–5 years of age who is inadequately immunised.

Index case and all room contacts, including staff, in a childcare group if index case attends >18 hours per week and any contacts <2 years of age who are inadequately immunised.

AND children who are not up to date with Hib should be immunised.

S. pneumoniae            

Nil

No increased risk to contacts