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Clinical Practice Guidelines

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Asthma (Acute)

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Assessment and Management

Severity

Signs of Severity

Management

Mild

Primary

Normal mental state

Subtle or no accessory muscle use/recession

Secondary

= O2 saturation > 95% in air

Able to talk normally

Salbutamol by MDI/spacer * - once and review after 20 mins. Ensure device / technique appropriate.

Good response - discharge on B2-agonist as needed.

Poor response - treat as moderate.

Oral prednisolone (1 mg/kg daily for 1-3 days) if on prophylaxis or episode has persisted over several days.

Provide written advice on what to do if symptoms worsen. Consider overall control and familyxs knowledge. Arrange follow-up as appropriate.

(discharge pack)

Moderate

Primary

Normal mental state

Some accessory muscle use/recession

Secondary

= O2 saturation 92-95% in air

Tachycardia

Some limitation of ability to talk

Give O2 if O2 saturation is < 92%. Need for O2 should be reassessed.

Salbutamol by MDI/spacer - 1 dose* every 20 minutes for 1 hour ; review 10-20 min after 3rd dose to decide on admission or discharge.

Oral prednisolone (1 mg/kg daily for 3 days)

The few children of moderate severity who can go home must be discussed with the registrar and should not leave Emergency until at least one hour after their last nebuliser. Arrange home treatment and follow-up as above.

Severe

Primary

Agitated/distressed

Moderate-marked accessory muscle use/recession

Secondary

= O2 saturation < 92% in air

Tachycardia

Marked limitation of ability to talk

Note: wheeze is a poor predictor of severity.

Oxygen.

Salbutamol by MDI/spacer- 1 dose*  every 20 minutes for 1 hour ; review on-going requirements 10-20 min after 3rd dose ? if improving reduce frequency, if no change continue 20 minutely, if deteriorating at any stage treat as critical.

Ipratropium# by MDI/spacer

Oral prednisolone (1 mg/kg daily); if vomiting give i.v. methylprednisolone.

Involve senior staff.

Arrange admission after initial assessment.

Critical

Primary

Confused/drowsy

Maximal accessory muscle use/recession

Exhaustion

Secondary

= SaO2 < 90% in air

Marked tachycardia

Unable to talk

Involve senior staff.

Call ICU registrar to assess patient (5211)

Oxygen.

Continuous nebulised salbutamol (0.5% undiluted) - see below re toxicity

Nebulised ipratropium 250 mcg 3 times in 1st hr only (20 minutely, added to salbutamol)

Methylprednisolone 1 mg/kg i.v. 6-hourly.

Aminophylline: If deteriorating or child is very sick

 
Loading dose: 10 mg/kg i.v. (maximum dose 500 mg) over 60 min. 

If currently taking oral theophylline, do not give i.v. aminophylline - take serum level.

Unless markedly improved, following loading dose give continuous infusion (usually in ICU), or 6 hourly dosing (usually in ward).

Infusion:
>12mo and <35kg, 55 mg/kg in 50ml 5%dex-hep at 1ml/hr (1.1mg/kg/hr)
 
>35kg and <17yr,  25 mg/ml (neat solution) at 0.028ml/kg/hr (0.7mg/kg/hr)
 
 
6 hourly dosing: 
>12mo and <35kg, 6mg/kg IV over 1hr
 
>35kg and <17yr, 4mg/kg IV over 1hr
 
 
Check theophylline level if patient continuing on aminophylline beyond loading dose.
 
 
Can also give i.v. salbutamol 5 mcg/kg/min for one hour as a load, followed by 1-2 mcg/kg/min
Aminophylline and salbutamol must be given via separate IV lines.


Beware salbutamol toxicity: tachycardia, tachypnoea, metabolic acidosis. Can occur with both IV and inhaled therapy. Lactate commonly high. Consider stopping/reducing salbutamol as a trial if you think this may be the problem.

  • = The arterial oxygen saturation (SaO2) may be reduced in the absence of significant airway obstruction by factors such as atelectasis and mucous plugging of airways. SaO2 is purely a measure of oxygenation, which may be preserved in the presence of deteriorating ventilation (with CO2 retention).
  • * salbutamol 6 puffs if < 6 years old, 12 puffs if >6 years old
  • # ipratropium (Atrovent 20mcg/puff) 4 puffs if < 6 years old, 8 puffs if >6 years old

History

Inquire specifically about the duration and nature of symptoms, treatments used (relievers, preventers), trigger factors (including upper respiratory tract infection, allergy, passive smoking), pattern and course of previous acute episodes (eg. admission or ICU admissions), parental understanding of the treatment of acute episodes, and the presence of interval symptoms (see Long Term Asthma Control below).

Consider other causes of wheeze (eg. bronchiolitis, mycoplasma, aspiration, foreign body)

Examination

The most important parameters in the assessment of the severity of acute childhood asthma are general appearance/mental state and work of breathing (accessory muscle use, recession), as indicated in the table. Initial SaO2 in air, heart rate and ability to talk are helpful but less reliable additional features. Wheeze intensity, pulsus paradoxus, and peak expiratory flow rate are not reliable.

Asymmetry on auscultation is often found due to mucous plugging, but warrants consideration of foreign body.

Investigations

Chest x-ray is not generally required (discuss with registrar/consultant if considering). Arterial blood gas and spirometry are rarely required in the assessment of acute asthma in children.

Notes

Long Term Asthma Control

  • The frequency of acute episodes and any chronic symptoms should be reviewed.
  • Specific questions should be asked about sleep disturbance (due to asthma), early morning symptoms, exercise induced cough or wheeze, and frequency of bronchodilator use.

Preventive Treatment

  • Consider preventive treatment if there are frequent acute episodes or chronic symptoms (more than one disturbed night per week, difficulty participating in physical activities, or bronchodilator use on more than one day per week).
  • First choice :  inhaled corticosteroids.
  • If commencing preventive treatment arrange early paediatric review.
  • Careful attention must be paid to the delivery system chosen. Spacer devices should be used at all ages. A low volume spacer device with a well-sealing face mask should be used in younger children.

Discharge

  • Each child should have a written action plan. This can be generated on the intranet Asthma action plan.
  • Observe inhaler technique before discharge.
  • Advise parents to seek further medical attention (preferably from their GP) should the patientxs condition deteriorate or if there is no significant improvement within 48 hours.
  • At discharge all patients should have an outpatient appointment or appropriate follow-up arranged with a paediatrician and/or GP. Newly diagnosed patients should be referred to a paediatrician for review within 4-6 weeks.
  • Parents should be informed of other sources of information about asthma such as the Asthma Foundation, and the Child Health Information Center (in RCH foyer)

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