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Dr Michael Cheung

Name:  Michael Cheung

Degrees:

• BSc. (Hons)
• MB ChB
• MRCP (UK)
• Certificate of Specialist Training in Paediatric Cardiology (UK) July 2004

Undergraduate Education:  University of Bristol, Medical School, UK

Awards

•  Roussel Pharmaceuticals Bursary, 1988

• Heart and Stroke Foundation of Canada Research Fellowship, 2002-2004      

• Salaried Clinical Research position for 2 years.

• Young Investigator Award, British Paediatric Cardiology Association, 2003

Research

• Warnock D.W., Oliver D.A., Cheung M., Zurich NJ.

  Effect of Methotrexate on the germination and growth of Aspergillus fumigatus and Aspergillus flavus strains.

  Journal of Antimicrobial Chemotherapy 1992;29(4) 375-81May 1999-April 2001
  

• Cheung MMH, Davis AM, Cohen RJ, Wilkinson.JL.

  T Wave Alternans Threshold in Normal Children.

  J. Card. Electrophysiology 2001;12(4) 428-430 .

• Doyle LW, Cheung MMH, Ford GW, Olinsky A, Davis NM, Callanan C.

  Birth weight <1501g and respiratory health at 14.

  Archives Diseases in Childhood 2001;84:40-44

• Cheung MMH, Weintraub RG, Cohen RJ, Karl TR, Wilkinson JL, Davis AM.

  T wave alternans threshold late after repair of tetralogy of Fallot.

  J Cardiovasc Electrophysiol 2002;13(7):657-61

• Vogel M, Rhabek-Schmidt M, Kristiansen SB, Cheung M, White PA, Sorensen K, Redington AN.

  Validation of myocardial acceleration during isovolumic contraction (IVA) as a novel non-invasive index of RV contractility. Comparison with ventricular pressure-volume relations in an animal model.

  Circulation. 2002 Apr 9;105(14):1693-9

• Vogel M, Cheung MMH, Li J, Kristiansen SB, Schmidt MR, White PA, Sorensen K, Redington AN.

  Non-invasive assessment of LV force-frequency relationships using tissue Doppler derived isovolumic acceleration: Validation in an animal model.

  Circulation. 2003 Apr 1;107(12):1647-52.

• Nugent AW, Daubeney PE, Chondros P, Carlin JB, Cheung M, Wilkinson LC, Davis AM, Kahler SG, Chow CW, Wilkinson JL, Weintraub RG.

  The epidemiology of childhood cardiomyopathy in Australia.

  New England Journal of Medicine 2003. 348 (17):1639-1646

• Cheung MMH, Li J, White PA, Smallhorn JF, Redington AN, Vogel M.

  Tissue Doppler Echocardiography; Can transesophageal echocardiography be used to acquire functional data?

  J Am Soc Echocardiogr. 2003 Jul;16(7):732-7.

• Cheung MMH, Sullivan ID, DeLeval M, Tsang VT, Redington AN.

  Optimal timing of the Ross procedure in the young with chronic aortic incompetence.

  Cardiol Young. 2003;13(3):253-7.

• Cheung MMH, Davis AM. Wilkinson JL, Weintraub RG.

  Long-term somatic growth after transatrial transpulmonary repair of tetralogy of  Fallot: Evidence for restoration of genetic growth potential.

  Heart. 2003 Nov;89(11):1340-3.

• Cheung MMH, Goldman AP, Shekerdemian LS, Brown KL, Cohen GA, Redington, AN.

  Percutaneous left ventricular “vent” insertion for left heart decompression during ECMO.          

  Pediatr Crit Care Med. 2003 Oct;4(4):447-9

• Li J, Stokoe J, Konstantinov IE, Edgell D, Cheung MM, Kharbanda RK, Redington AN.
  
  Continuous measurement of oxygen consumption during cardiopulmonary bypass: description of the method and in vivo observations.
  Ann Thorac Surg. 2004 May;77(5):1671-7.

• Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, Downey GP, Liu PP, Cukerman E, Coles JG, Redington AN.

  The Remote Ischemic Preconditioning Stimulus Modifies Inflammatory Gene Expression in Humans.

  Physiol Genomics. 2004 Sep 16;19(1):143-50.

• Cheung MMH, Redington AN.

  Assessment of myocardial ventricular function in donor hearts: is isovolumic acceleration measured by tissue Doppler the Holy Grail? J Heart Lung Transplant. 2004;23(9 Suppl):S253-6.

• Cheung MMH, Smallhorn JF, Redington AN, Vogel M.

  The effects of changes in loading conditions and modulation of inotropic state on the myocardial performance index; comparison with conductance catheter measurements.

  Eur Heart J. 2004 Dec;25(24):2238-42.

• Cheung M, Redington A, Vogel M, Schmidt M, Sorensen K.
  
  Influence of preload alterations on parameters of systolic left ventricular long-axis function: a Doppler tissue study: flawed methodology leads to spurious results. J Am Soc Echocardiogr. 2005 Mar;18(3):298.

• Shimizu M, Konstantinov IE, Suess AM, Cheung M, McCrindle BW, Vogel M, Redington AN.
  
  Noninvasive analysis of myocardial function using high-resolution Doppler tissue echocardiography in rats. J Am Soc Echocardiogr. 2005 May;18(5):461-7.

• Konstantinov IE, Li J, Cheung MM, Shimizu M, Stokoe J, Kharbanda RK, Redington AN.
  
  Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism. Transplantation. 2005 Jun 27;79(12):1691-5.

• Cheung MM, Konstantinov IE, Redington AN.
  
  Late complications of repair of tetralogy of fallot and indications for pulmonary valve replacement. Semin Thorac Cardiovasc Surg. 2005 Summer;17(2):155-9.

• Nugent AW, Daubeney PE, Chondros P, Carlin JB, Colan SD, Cheung M, Davis AM, Chow CW, Weintraub RG;
  
  National Australian Childhood Cardiomyopathy Study.
  Clinical features and outcomes of childhood hypertrophic cardiomyopathy: results from a national population-based study. Circulation. 2005 Aug 30;112(9):1332-8.

• Konstantinov IE, Arab S, Li J, Coles JG, Boscarino C, Mori A, Cukerman E, Dawood F,Cheung MM, Shimizu M, Liu PP, Redington AN.
  
  The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium. J Thorac Cardiovasc Surg. 2005 ;130:1326-32.

• Cheung MMH, Smallhorn JF, McCrindle B, Van Arsdell GS, Redington AN.

  Non-invasive assessment of ventricular force-frequency relationships in the univentricular circulation by tissue Doppler echocardiography; a novel method of assessing myocardial performance in congenital heart disease. Heart. 2005; 91:1338-42.

• Cheung MM, Redington AN, Schmidt MR, Sorensen KE, Vogel M.
  
  Letter regarding article by Lyseggen et al, "Myocardial acceleration during isovolumic contraction: relationship to contractility". Circulation. 2005;112:e135.

• Kharbanda RK, Li J, Cheung MMH, Konstantinov I, White PA, Frndova H, Stokoe J, Cox PN, Vogel M, Van Arsdell GS, MacAllister R, Redington AN.

  Remote ischemic preconditioning protects from cardiopulmonary bypass injury in vivo.

  Heart 2006. In press.

• Cheung MMH, Smallhorn JF, Van Arsdell GS, Redington AN.

  Disruption of the Myocardial Force-Frequency Relationship Following Cardiopulmonary Bypass; first Human Data and Implications for Postoperative Care. JTCVS 2006. In press.

• Cheung MMH, Kharbanda RK, Konstantinov IE, Shimizu M, Frndova H, Li J, Holtby HM, Cox PN, Smallhorn JF,  Van Arsdell GS, Redington AN.

  Randomised controlled trial of the effects of remote ischemic preconditioning on patients undergoing cardiac surgery; first clinical application in humans.

  Journal of the American College of Cardiology 2006. In press.

Book Chapters

• Cheung MMH and Benson LN.
  
  Considerations in Catheter Interventions.
  In “Ventricular Function and Blood Flow in Congenital Heart Disease”, Futura Inc., 2005.
  
• Cheung MMH and Redington AN.
  
  "Systolic and diastolic function"
  In "Heart failure in children and young adults: From molecular mechanisms to medical and surgical strategies", Elsevier Inc.,2005. Eds. Anthony Chang and Jeffrey Towbin.

Invited Speaker

• Assessment of arrhythmia risk in repaired tetralogy of Fallot.
  Cardiac Society of Australia and New Zealand 2000.
  
• Outcome and late follow-up of coarctation. Cardiology in Neonates and Infants,
  National Heart and Lung Institute, 2004.
  
• Heart failure in early infancy; Pathophysiology and clinical eveluation in the common lesions. Cardiology in Neonates and Infants,
  National Heart and Lung Institute, 2004.
  
• Right ventricular physiology in repaired tetralogy of Fallot.
  Canadian Cardiovascular Society meeting, Calgary 2004.
  
• Assessment of ventricular function by magnetic resonance imaging.
  British Paediatric Cardiology Association Annual Meeting, Dublin 2004.
  
• Tissue Doppler Echocardiography.
  3^rd SPR Cardiovascular Magnetic Resonance Imaging Symposium, Toronto 2005. 
  
• When should we perform transcatheter pulmonary valve replacement?
  1^st Annual Toronto Symposium, Toronto May 2005