Cardiology Department

RCH > Surgery > Cardiology

Professor Dan Penny - Publications

Recent Publications

Stocker CF, Shekerdemian LS, Norgaard MA, Brizard CP, Mynard JP, Horton SB, Penny DJ. Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass. Critical care medicine. 2007;35:252-259.

McMullan DM, Oppido G, Davies B, Kawahira Y, Cochrane AD, d'Udekem d'Acoz Y, Penny DJ, Brizard CP. Surgical strategy for the bicuspid aortic valve: tricuspidization with cusp extension versus pulmonary autograft. The Journal of thoracic and cardiovascular surgery. 2007;134:90-98.

Dumitrescu A, Lane GK, Wilkinson JL, Goh TH, Penny DJ, Davis AM. Transcatheter closure of perimembranous ventricular septal defect. Heart (British Cardiac Society). 2007;93:867; author reply 867.

d'Udekem Y, Iyengar AJ, Cochrane AD, Grigg LE, Ramsay JM, Wheaton GR, Penny DJ, Brizard CP. The Fontan procedure: contemporary techniques have improved long-term outcomes. Circulation. 2007;116:I157-164.

Chew C, Halliday JL, Riley MM, Penny DJ. Population-based study of antenatal detection of congenital heart disease by ultrasound examination. Ultrasound Obstet Gynecol. 2007;29:619-624.

Simpson CM, Penny DJ, Stocker CF, Shekerdemian LS. Urotensin II is raised in children with congenital heart disease. Heart (British Cardiac Society). 2006;92:983-984.

Simpson CM, Penny DJ, Cochrane AD, Davis AM, Rose ML, Wilson SE, Weintraub RG. Preliminary experience with bosentan as initial therapy in childhood idiopathic pulmonary arterial hypertension. J Heart Lung Transplant. 2006;25:469-473.

Ryammer PK, Shekerdemian LS, Penny DJ, Ravn HB. Effect of intravenous sildenafil on pulmonary hemodynamics and gas exchange in the presence and absence of acute lung injury in piglets. Pediatric research. 2006;59:762-766.

Penny DJ. The systemic delivery and consumption of oxygen in the infant after cardiac surgery. Cardiology in the young. 2006;16 Suppl 3:144-150.

Chew C, Stone S, Donath SM, Penny DJ. Impact of antenatal screening on the presentation of infants with congenital heart disease to a cardiology unit. Journal of paediatrics and child health. 2006;42:704-708.

McMahon CJ, Penny DJ, Nelson DP, Ades AM, Al Maskary S, Speer M, Katkin J, McKenzie ED, Fraser CD, Jr., Chang AC. Preterm infants with congenital heart disease and bronchopulmonary dysplasia: postoperative course and outcome after cardiac surgery. Pediatrics. 2005;116:423-430.

Maskari SN, Cochrane AD, Penny DJ. Unusual cause of persistent impairment of ventricular function after repair of coarctation of the aorta. Pediatric cardiology. 2005;26:836-838.

Horton SB, Penny DJ. Extracorporeal cardiopulmonary resuscitation: another piece of the jigsaw. Critical care medicine. 2005;33:1659-1660.

Hayes IM, Varigos G, Upjohn EJ, Orchard DC, Penny DJ, Savarirayan R. Unilateral acheiria and fatal primary pulmonary hypertension in a girl with incontinentia pigmenti. American journal of medical genetics. 2005;135:302-303.

Stocker CF, Shekerdemian LS, Visvanathan K, Skinner N, Brizard CP, Carlin JB, Horton SB, Penny DJ. Cardiopulmonary bypass elicits a prominent innate immune response in children with congenital heart disease. The Journal of thoracic and cardiovascular surgery. 2004;127:1523-1525.

Shekerdemian LS, Ravn HB, Penny DJ. Interaction between inhaled nitric oxide and intravenous sildenafil in a porcine model of meconium aspiration syndrome. Pediatric research. 2004;55:413-418.

Shekerdemian LS, Penny DJ, Ryhammer PK, Reader JA, Ravn HB. Endothelin-A receptor blockade and inhaled nitric oxide in a porcine model of meconium aspiration syndrome. Pediatric research. 2004;56:353-358.

Penny DJ, Taib R. What's Happening in Paediatric Cardiology? Heart, lung & circulation. 2004;13 Suppl 3:S24-30.

Li J, Stenbog E, Bush A, Grofte T, Redington AN, Penny DJ. Insulin-like growth factor 1 improves the relationship between systemic oxygen consumption and delivery in piglets after cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery. 2004;127:1436-1441.

Hughes ML, Shekerdemian LS, Brizard CP, Penny DJ. Improved early ventricular performance with a right ventricle to pulmonary artery conduit in stage 1 palliation for hypoplastic left heart syndrome: evidence from strain Doppler echocardiography. Heart (British Cardiac Society). 2004;90:191-194.

Chen R, Penny DJ, Greve G, Lab MJ. Rate dependence of mechanically induced electrophysiological changes in right ventricle of anaesthetized lambs during pulmonary artery occlusion. Acta physiologica Scandinavica. 2004;180:13-19.

Penny DJ. Ischaemic preconditioning: Developing knowledge of a developing process. Heart, lung & circulation. 2003;12:8-10.

Marwah A, Soto R, Penny DJ. Critical pulmonary stenosis with an aortopulmonary window. Cardiology in the young. 2003;13:484-485.

Brown KL, Ridout DA, Goldman AP, Hoskote A, Penny DJ: Risk factors for long intensive care unit stay after cardiopulmonary bypass in children. Crit Care Med. 2003;31:28-33

Gray R, Greve G, Chen R, Fry C, Barron D, Lab MJ, White PA, Redington AN, Penny DJ: Right ventricular myocardial responses to chronic pulmonary regurgitation in lambs: disturbances of activation and conduction. Pediatr.Res. 2003;54:529-535

Li J, Bush A, Schulze-Neick I, Penny DJ , Redington AN, Shekerdemian LS: Measured versus estimated oxygen consumption in ventilated patients with congenital heart disease: the validity of predictive equations. Crit Care Med. 2003;31:1235-1240

Martin AC, Rigby ML, Penny DJ, Redington AN: Bedside balloon atrial septostomy on neonatal units. Arch.Dis.Child Fetal Neonatal Ed 2003;88:F339-F340

Penny DJ, Rose M, Wilson S, Davis AM, Weintraub RG: Preliminary experience with Bosentan in children with primary pulmonary hypertension. J.Am.Coll.Cardiol. 2003;41:485

Penny DJ, Somerville J, Caplin JL, Redington AN: Transcatheter closure of an atrial septal defect after a road traffic crash. J.Trauma 2003;55:559-560

Stocker C, Penny DJ, Brizard CP, Cochrane AD, Soto R, Shekerdemian LS: Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery. Intensive Care Med. 2003;29:1996-2003

Penny DJ, Smolich JJ. Divergent effects of NO synthase inhibition on systemic and myocardial O2 delivery and consumption during dobutamine infusion in sheep. Pflugers Arch. 2002;443:601-608.

Brown KL, Shekerdemian LS, Penny DJ: Transcatheter closure of a patent arterial duct in a patient on veno-arterial extracorporeal membrane oxygenation. Intensive Care Med. 2002;28:501-503

Kumar P, Roy A, Penny DJ, Ladas G, Goldstraw P: Airway obstruction and ventilator dependency in young children with congenital cardiac defects: a role for self-expanding metal stents. Intensive Care Med. 2002;28:190-195

Penny DJ , Smolich JJ: Divergent effects of NO synthase inhibition on systemic and myocardial O2 delivery and consumption during dobutamine infusion in sheep. Pflugers Arch. 2002;443:601-608

Schulze-Neick I, Li J, Reader JA, Shekerdemian L, Redington AN, Penny DJ: The endothelin antagonist BQ123 reduces pulmonary vascular resistance after surgical intervention for congenital heart disease. J.Thorac.Cardiovasc.Surg. 2002;124:435-441

Shekerdemian LS, Ravn HB, Penny DJ: Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. Am.J.Respir.Crit Care Med. 2002;165:1098-1102

Penny DJ, Sano T, Smolich JJ. Increased systemic oxygen consumption offsets improved oxygen delivery during dobutamine infusion in newborn lambs. Intensive care medicine. 2001;27:1518-1525.

Abrams D, Derrick G, Penny DJ , Shinebourne EA, Redington AN: Cardiac complications in children following infection with varicella zoster virus. Cardiol.Young. 2001;11:647-652

Greve G, Lab MJ, Chen R, Barron D, White PA, Redington AN, Penny DJ: Right ventricular distension alters monophasic action potential duration during pulmonary arterial occlusion in anaesthetised lambs: evidence for arrhythmogenic right ventricular mechanoelectrical feedback. Exp.Physiol 2001;86:651-657

Schulze-Neick I, Li J, Penny DJ, Redington AN: Pulmonary vascular resistance after cardiopulmonary bypass in infants: effect on postoperative recovery. J Thorac.Cardiovasc.Surg. 2001;121:1033-1039

Penny DJ, Shekerdemian LS. Management of the neonate with symptomatic congenital heart disease. Arch Dis Child Fetal Neonatal Ed. 2001 May;84(3):F141-5.

Derrick GP, Narang I, White PA, Kelleher A, Bush A, Penny DJ, Redington AN. Failure of stroke volume augmentation during exercise and dobutamine stress is unrelated to load-independent indexes of right ventricular performance after the Mustard operation. Circulation. 2000 Nov 7;102(19 Suppl 3):III154-9.

Schulze-Neick I, Ho SY, Bush A, Rosenthal M, Franklin RC, Redington AN, Penny DJ. Severe airflow limitation after the unifocalization procedure: clinical and morphological correlates. Circulation. 2000 Nov 7;102(19 Suppl 3):III142-7.

Schulze-Neick I, Penny DJ, Derrick GP, Dhillon R, Rigby ML, Kelleher A, Bush A, Redington AN. Pulmonary vascular-bronchial interactions: acute reduction in pulmonary blood flow alters lung mechanics. Heart. 2000 Sep;84(3):284-9.

Mas C, Penny DJ, Menahem S. Pre-excitation syndrome secondary to cardiac rhabdomyomas in tuberous sclerosis. J Paediatr Child Health. 2000 Feb;36(1):84-6.

Cheung YF, Penny DJ, Redington AN. Serial assessment of left ventricular diastolic function after Fontan procedure. Heart. 2000 Apr;83(4):420-4.

Li J, Schulze-Neick I, Lincoln C, Shore D, Scallan M, Bush A, Redington AN, Penny DJ Oxygen consumption after cardiopulmonary bypass surgery in children: determinants and implications. J Thorac Cardiovasc Surg. 2000 Mar;119(3):525-33.

Shekerdemian LS, Schulze-Neick I, Redington AN, Bush A, Penny DJ Negative pressure ventilation as haemodynamic rescue following surgery for congenital heart disease. Intensive Care Med. 2000 Jan;26(1):93-6.

Shekerdemian LS, Penny DJ, Novick W. Early extubation after surgical repair of tetralogy of Fallot. Cardiol Young. 2000 Nov;10(6):636-7.

Smolich JJ, Sano T, Penny DJ Blunting of pulmonary but not systemic vasodilator responses to dobutamine. Pediatr Res. 2000 Jan;47(1):107-13.

Schulze-Neick I, Penny DJ, Rigby ML, Morgan C, Kelleher A, Collins P, Li J, Bush A, Shinebourne EA, Redington AN. L-arginine and substance P reverse the pulmonary endothelial dysfunction caused by congenital heart surgery. Circulation. 1999 Aug 17;100(7):749-55.

Zhang J, Penny DJ, Kim NS, Yu VY, Smolich JJ. Mechanisms of blood pressure increase induced by dopamine in hypotensive preterm neonates. Arch Dis Child Fetal Neonatal Ed. 1999 Sep;81(2):F99-F104.

Penny DJ . The basics of ventricular function. Cardiol Young. 1999 Mar;9(2):210-23. Review.

Schulze-Neick I, Werner H, Penny DJ, Alexi-Meskishvili V, Lange PE. Acute ventilatory restriction in children after weaning of inhaled nitric oxide: relation to rebound pulmonary hypertension. Intensive Care Med. 1999 Jan;25(1):76-80.

Book Chapters

Penny DJ. Univentricular Atrioventricular Connection. In : Paediatric Cardiology. Eds. Anderson RH et al. 2nd Ed. Churchill-Livingstone. 2001

Penny DJ. Ventricular Function . In: Paediatric Cardiology Eds. Anderson RH et al 2nd Ed. Churchill-Livingstone 2001

Penny DJ, Redington AN. Assessment of Ventricular Function. In: The Left Heart in Congenital Heart Disease. Eds. Redington AN, Deanfield JE & Anderson RH. Greenwich Medical, London 2001.

Tsang VT, Penny DJ. Surgery for congenital heart disease. In: Essentials of Thoracic and Cardiac Surgery (2nd Ed). Eds. Moghissi K, Thorpe JAC, Ciulli F 2001

Last Updated 28-Jul-2008. Authorised by: Jim Wilkinson. Enquiries: Adam Leadoux.