Albumin Administration

  • Albumin Administration

    Description

    Albumin comes in two concentrations:

    1. 4% Albumex is a 4% protein solution, which is iso-osmotic with human serum.  It comes in two sizes 2g human albumin in 50ml or 20g human albumin in 500mls.
    2. 20% Albumex ia a 20% protein solution, which is hyper-osmotic with human serum.  It comes in two sizes 2g human albumin in 10mls and 20g human albumin in 100mls.

    Clinical indications for the use of albumin

    4% Albumin is commonly administered for the following conditions:

    • Shock associated with significant hypoalbuminaemia
    • Therapeutic plasma exchange
    • Cardiothoracic surgery, to prime the pump in patients with poor left ventricular function and other complicating factors.

    20% Albumin is commonly administered for the following conditions:

    • Extremely low albumin in critically-ill patients
    • Burns
    • Paracentesis of ascites in patients with cirrhosis or when the volume exceeds 6L.
    • Haemodialysis 

    Storage

    Albumex should be stored below 30 degrees C and protected from light.  Albumex must not be frozen and should not be used beyond its expiry date.

    Administration

    Albumex should be administered through a standard IV giving set (no filter required).  As Albumex has no antimicrobial properties or additives the manufacturer recommends that is used immediately. Australian Red Cross Blood Service ARCBS recommends that each bottle of Albumex is used within 4 hours.

    Observations

    Standard routine observations are required when administering an Albumin infusion.  Albumin is a highly processed/treated plasma derivative and transfusion reactions are not known to occur with administration of this product.