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Treatment Non Responsive Program

Key findings (2004)

1. a subgroup of anxious pre-pubertal children with ADHD, combined type (ADHD-CT) are genuinely psychostimulant medication treatment non-responsive in the short- and longer-terms
   
   
2. a subgroup of dysthymic pre-pubertal children with ADHD-CT may be responsive to intensive psychotherapy delivered over a three month period to both the child and the parent-child dyad(s)
   
   
3. dysthymic disorder independently contributes to the severity of oppositional defiant disorder in pre-pubertal children with ADHD-CT

Key findings (2005)

1. A subgroup of anxious pre-pubertal children with ADHD-CT may have comorbid dysthymic disorder that has been previously unrecognised.
   
   
2. Children with ADHD-CT and dysthymic disorder have significantly greater parental psychopathology than children with either disorder alone: this effect appears to be multiplicative.
   
   
3. Imipramine (TCA) and fluoxetine (SSRI) are helpful in children with ADHD-CT and comorbid dysthymic disorder: they aid better mood and arousal regulation.

Key findings (2006) 

1. Children and adolescents with ADHD, combined type demonstrate improved working memory with short and long term stimulant medication use.
   
   
2. Children and adolescents with ADHD, combined type and comorbid type ODD / CD do not demonstrate improved working memory with short and long term stimulant  medication use.
   
   
3. Children and adolescents with dysthymic disorder demonstrate improved improved working memory with short and long term stimulant medication use.

Key findings (2007)

1. Children and adolescents with ADHD, combined type and comorbid anxiety (without dysthymic disorder) demonstrate improved working memory with short and long term stimulant medication use.
   
   
2. Children and adolescents with dysthymic disorder do not demonstrate improved working memory with short and long term stimulant medication use.
   
   
3. Children and adolescents with OCD do not demonstrate improved working memory with short and long term stimulant  medication use.